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Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

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  • Kouji Hirota

    (Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan
    Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan
    Present address: Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.)

  • Tomoichiro Miyoshi

    (Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan)

  • Kazuto Kugou

    (Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan
    Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan)

  • Charles S. Hoffman

    (Boston College, Chestnut Hill, Massachusetts 02467, USA)

  • Takehiko Shibata

    (Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan)

  • Kunihiro Ohta

    (Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan
    Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan)

Abstract

Non-coding RNAs active in chromatin remodellng Non-coding RNAs are abundant, yet their function is still largely unknown. Here, non-coding RNA transcripts are detected at the fission yeast fbp1+ locus, upstream of the normal transcription initiation site. Transcription of these non-coding RNAs through the promoter region of fbp1+ is required for chromatin remodelling and robust activation of fbp1+ during glucose starvation. This study provides evidence for a role for ncRNAs in RNAPII transcription during the formation of transcriptionally-active chromatin, hinting at a potentially important biological role for ncRNAs observed in higher eukaryotes.

Suggested Citation

  • Kouji Hirota & Tomoichiro Miyoshi & Kazuto Kugou & Charles S. Hoffman & Takehiko Shibata & Kunihiro Ohta, 2008. "Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs," Nature, Nature, vol. 456(7218), pages 130-134, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7218:d:10.1038_nature07348
    DOI: 10.1038/nature07348
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