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The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Author

Listed:
  • Aubin Penna

    (Department of Physiology and Biophysics,)

  • Angelo Demuro

    (and)

  • Andriy V. Yeromin

    (Department of Physiology and Biophysics,)

  • Shenyuan L. Zhang

    (Department of Physiology and Biophysics,)

  • Olga Safrina

    (Department of Physiology and Biophysics,)

  • Ian Parker

    (Department of Physiology and Biophysics,
    and)

  • Michael D. Cahalan

    (Department of Physiology and Biophysics,
    Center for Immunology, University of California Irvine, California 92697-4561, USA)

Abstract

CRAC channels: dimerization the key? The mechanism underlying activation of Ca2+ release-activated Ca2+ channels, in response to depletion of intracellular Ca2+ stores, has generated much interest. Recently, it was shown that Stim forms the relay between the Ca2+ store and the plasma membrane, where it activates the ion-channel forming protein Orai. Here, Penna et al. show that Orai is a dimer at rest and a tetramer when activated by Stim, raising the interesting possibility that dimerization is the trigger for channel activation.

Suggested Citation

  • Aubin Penna & Angelo Demuro & Andriy V. Yeromin & Shenyuan L. Zhang & Olga Safrina & Ian Parker & Michael D. Cahalan, 2008. "The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers," Nature, Nature, vol. 456(7218), pages 116-120, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7218:d:10.1038_nature07338
    DOI: 10.1038/nature07338
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