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GILT is a critical host factor for Listeria monocytogenes infection

Author

Listed:
  • Reshma Singh

    (Department of Immunobiology,
    Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250-8011, USA)

  • Amanda Jamieson

    (Department of Immunobiology,
    Present address: Max F. Perutz Laboratories GmbH, Rennweg 95a, 1030 Wien 3, Landstraße, Wiene A1030, Austria.)

  • Peter Cresswell

    (Department of Immunobiology,
    Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250-8011, USA)

Abstract

Listeriosis: host's GILT aids infection The bacterium Listeria monocytogenes is a food-borne pathogen that can cause severe illness in humans and animals. Now the enzyme GILT (interferon-γ-inducible lysosomal thiol reductase) has been identified as a critical host factor for infection by L. monocytogenes. Once in the body Listeria produces a pore-forming toxin, listeriolysin O (LLO), that releases phagocytosed bacteria into the cytosol of macrophages where they can replicate. LLO needs to be reduced before it becomes active, and it is the host's GILT enzyme that mediates this reduction. Mice lacking GILT are resistant to Listeria. This work offers a new potential therapeutic target for a disease where antibiotic resistance is of growing concern.

Suggested Citation

  • Reshma Singh & Amanda Jamieson & Peter Cresswell, 2008. "GILT is a critical host factor for Listeria monocytogenes infection," Nature, Nature, vol. 455(7217), pages 1244-1247, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7217:d:10.1038_nature07344
    DOI: 10.1038/nature07344
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