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Structural insights into amino acid binding and gene control by a lysine riboswitch

Author

Listed:
  • Alexander Serganov

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • Lili Huang

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

Abstract

Riboswitch mechanisms Riboswitches are structured RNAs that can bind a ligand such as a metabolite or nucleobase. Binding of the ligand affects the function of the RNA, so that they are often found in regulatory loops. In this work Patel and colleagues report the structure of a riboswitch that binds the amino acid lysine. The scaffold of the riboswitch is preassembled, but conformational changes occur upon binding lysine that direct further changes in the RNA downstream of the switch. Structures of the riboswitch with lysine analogues, including an antibiotic, provide some insight the development of resistance.

Suggested Citation

  • Alexander Serganov & Lili Huang & Dinshaw J. Patel, 2008. "Structural insights into amino acid binding and gene control by a lysine riboswitch," Nature, Nature, vol. 455(7217), pages 1263-1267, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7217:d:10.1038_nature07326
    DOI: 10.1038/nature07326
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    Cited by:

    1. Zhou Gong & Yunjie Zhao & Changjun Chen & Yong Duan & Yi Xiao, 2014. "Insights into Ligand Binding to PreQ1 Riboswitch Aptamer from Molecular Dynamics Simulations," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-12, March.

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