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Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Author

Listed:
  • Xiaocong Yu

    (Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA)

  • Tshidi Tsibane

    (Mount Sinai School of Medicine)

  • Patricia A. McGraw

    (Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA)

  • Frances S. House

    (Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA)

  • Christopher J. Keefer

    (Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA)

  • Mark D. Hicar

    (Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA)

  • Terrence M. Tumpey

    (Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA)

  • Claudia Pappas

    (Mount Sinai School of Medicine
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA)

  • Lucy A. Perrone

    (Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA)

  • Osvaldo Martinez

    (Mount Sinai School of Medicine)

  • James Stevens

    (Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    The Scripps Research Institute, La Jolla, California 92037, USA)

  • Ian A. Wilson

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Patricia V. Aguilar

    (Mount Sinai School of Medicine)

  • Eric L. Altschuler

    (University of Medicine & Dentistry of New Jersey, Newark, New Jersey 07103, USA)

  • Christopher F. Basler

    (Mount Sinai School of Medicine)

  • James E. Crowe Jr

    (Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA)

Abstract

A lifetime fighting flu The isolation of neutralizing antibodies to proteins from the 1918 H1N1 influenza virus from the blood of pandemic survivors sets a new yardstick for the persistence of an immune response. The blood samples were collected from 32 survivors aged between 91 and 101 years. They were 2 to 12 years old in 1918. All were seroreactive to the recently re-created 1918 virus, and it was possible to isolate memory B cells from some of the samples and grow them in culture. The B cells produced antibodies to a 1918 virus protein that protected mice from lethal infection by the 1918 virus. This suggests that they could serve as potential therapeutics of an emergent 1918-like virus.

Suggested Citation

  • Xiaocong Yu & Tshidi Tsibane & Patricia A. McGraw & Frances S. House & Christopher J. Keefer & Mark D. Hicar & Terrence M. Tumpey & Claudia Pappas & Lucy A. Perrone & Osvaldo Martinez & James Stevens , 2008. "Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors," Nature, Nature, vol. 455(7212), pages 532-536, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7212:d:10.1038_nature07231
    DOI: 10.1038/nature07231
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