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Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection

Author

Listed:
  • Liliana Soroceanu

    (California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA)

  • Armin Akhavan

    (California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA)

  • Charles S. Cobbs

    (California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA
    University of California, San Francisco, 787 Moffitt, 505 Parnassus Avenue, San Francisco, California 94143, USA)

Abstract

Human cytomegalovirus: dependence on PDGFR-α Human platelet derived growth factor-alpha (PDGFR-α) receptor has been found to be a requirement for the infection of human cells by human cytomegalovirus (HCMV), the herpesvirus that's the most common cause of congenital human infections, and causes life threatening disease in HIV-infected and transplant patients. If the receptor is inactivated, HCMV cannot enter the cell and viral genes are not expressed. Importantly, two currently available pharmaceutical agents — the anticancer drug imatinib (Gleevec) and PDGFR-α blocking antibody IMC-3G3 — are active against the virus in human cells suggesting that they might prove useful in the treatment of HCMV infection.

Suggested Citation

  • Liliana Soroceanu & Armin Akhavan & Charles S. Cobbs, 2008. "Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection," Nature, Nature, vol. 455(7211), pages 391-395, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7211:d:10.1038_nature07209
    DOI: 10.1038/nature07209
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