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Heterochromatin links to centromeric protection by recruiting shugoshin

Author

Listed:
  • Yuya Yamagishi

    (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences,
    Graduate Program in Biophysics and Biochemistry, Graduate School of Science, and,)

  • Takeshi Sakuno

    (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences,
    Promotion of Independence for Young Investigators, University of Tokyo, Yayoi, Tokyo 113-0032, Japan)

  • Mari Shimura

    (International Medical Center of Japan)

  • Yoshinori Watanabe

    (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences,
    Graduate Program in Biophysics and Biochemistry, Graduate School of Science, and,)

Abstract

Centromere function: mitosis versus meiosis The centromere of a chromosome contains regions of heterochromatin that have diverse roles during chromosome segregation. Here, the authors demonstrate in fission yeast that during mitosis, the main function for centromeric heterochromatin is to recruit cohesin. In contrast, during meiosis, the most important function for heterochromatin is to recruit the cohesin protector shugoshin to centromeres. This function is conserved in human cells.

Suggested Citation

  • Yuya Yamagishi & Takeshi Sakuno & Mari Shimura & Yoshinori Watanabe, 2008. "Heterochromatin links to centromeric protection by recruiting shugoshin," Nature, Nature, vol. 455(7210), pages 251-255, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7210:d:10.1038_nature07217
    DOI: 10.1038/nature07217
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