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Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes

Author

Listed:
  • Dacheng Tian

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University)

  • Qiang Wang

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University)

  • Pengfei Zhang

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University)

  • Hitoshi Araki

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
    EAWAG Center of Ecology, Evolution and Biogeochemistry)

  • Sihai Yang

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University)

  • Martin Kreitman

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Thomas Nagylaki

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Richard Hudson

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Joy Bergelson

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
    University of Chicago, Chicago, Illinois 60637, USA)

  • Jian-Qun Chen

    (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University)

Abstract

Mutation hotspots: the role of insertions and deletions Recent genomic efforts have demonstrated that large chunks of DNA differ between individuals in many species, and that the differences are focused on mutation hot-spots. Six pairwise comparisons of the distributions of single nucleotide substitutions around insertions and deletions ('indels') using ten genomes including yeast, rice, fly, rodent and primate show that the level of genetic variation is strongly and negatively correlated with the distance from indels in all the comparisons. Furthermore, the size and abundance of indels significantly influences the level of local nucleotide diversity. This work suggests that indels are a common mechanism to induce mutations, and may play an important role in genome evolution.

Suggested Citation

  • Dacheng Tian & Qiang Wang & Pengfei Zhang & Hitoshi Araki & Sihai Yang & Martin Kreitman & Thomas Nagylaki & Richard Hudson & Joy Bergelson & Jian-Qun Chen, 2008. "Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes," Nature, Nature, vol. 455(7209), pages 105-108, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7209:d:10.1038_nature07175
    DOI: 10.1038/nature07175
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    Cited by:

    1. Luke R. Tembrock & Frida A. Zink & Guozhe Zhang & Andrea Schuhmann & Cuihua Gu & Zhiqiang Wu, 2024. "Tracing the Maternal Line in Glacial–Interglacial Migrations of Populus tremuloides : Finding Trees for Future Sustainable Forests by Searching in the Past," Sustainability, MDPI, vol. 16(3), pages 1-18, January.

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