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Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

Author

Listed:
  • Xiaojing He

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Jie Zhou

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Mark Bartlam

    (College of Life Sciences and Tianjin State Laboratory of Protein Sciences, Nankai University)

  • Rongguang Zhang

    (Midwest Center for Structural Genomics and Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA)

  • Jianyuan Ma

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Zhiyong Lou

    (Laboratory of Structural Biology, Tsinghua University)

  • Xuemei Li

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
    Laboratory of Structural Biology, Tsinghua University)

  • Jingjing Li

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Andrzej Joachimiak

    (Midwest Center for Structural Genomics and Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA)

  • Zonghao Zeng

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Ruowen Ge

    (National University of Singapore)

  • Zihe Rao

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
    College of Life Sciences and Tianjin State Laboratory of Protein Sciences, Nankai University
    Laboratory of Structural Biology, Tsinghua University)

  • Yingfang Liu

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

Abstract

Influenza virus: polymerase structures determined Influenza A virus polymerase consists of three proteins, PA, PB1 and PB2, and is critical for transcription and replication. Two groups now report the crystal structure of the avian H5N1 PA C-terminal domain in complex with the PA binding domain of PB1. The structure work may be useful for the design of novel antiviral drugs.

Suggested Citation

  • Xiaojing He & Jie Zhou & Mark Bartlam & Rongguang Zhang & Jianyuan Ma & Zhiyong Lou & Xuemei Li & Jingjing Li & Andrzej Joachimiak & Zonghao Zeng & Ruowen Ge & Zihe Rao & Yingfang Liu, 2008. "Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus," Nature, Nature, vol. 454(7208), pages 1123-1126, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7208:d:10.1038_nature07120
    DOI: 10.1038/nature07120
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