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The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

Author

Listed:
  • Shigeo Takashima

    (Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Marianna Mkrtchyan

    (Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Amelia Younossi-Hartenstein

    (Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • John R. Merriam

    (Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Volker Hartenstein

    (Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA)

Abstract

Genetic control of stem cells Genetically tractable animals like Drosophila are ideal models for the study of the gene networks that control stem cell function. Takashima et al. now describe a novel system in Drosophila, the stem cells of the hindgut, that may be of value for the study of the specification and control of stem cells in general. As intestinal tract cells age, they are replaced by new ones produced by self-renewing intestinal stem cells (ISCs). In Drosophila the ISCs are confined to a narrow segment of the intestine, the hindgut proliferation zone (HPZ). Self renewal here is controlled by the Wingless (a Drosophila Wnt homologue) and Hedgehog signalling pathways in a manner that is remarkably similar to that seen in mammalian intestine.

Suggested Citation

  • Shigeo Takashima & Marianna Mkrtchyan & Amelia Younossi-Hartenstein & John R. Merriam & Volker Hartenstein, 2008. "The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling," Nature, Nature, vol. 454(7204), pages 651-655, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7204:d:10.1038_nature07156
    DOI: 10.1038/nature07156
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