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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Author

Listed:
  • Takeshi Saito

    (University of Washington School of Medicine, Seattle, Washington 98195-7650, USA)

  • David M. Owen

    (University of Washington School of Medicine, Seattle, Washington 98195-7650, USA
    UT Southwestern Medical Center, Dallas, Texas 75235-9048, USA)

  • Fuguo Jiang

    (Rutgers University, Piscataway, New Jersey 08854, USA)

  • Joseph Marcotrigiano

    (Rutgers University, Piscataway, New Jersey 08854, USA)

  • Michael Gale Jr.

    (University of Washington School of Medicine, Seattle, Washington 98195-7650, USA)

Abstract

Hepatitis C recognition Innate immunity is an important defence against infection by viruses, triggered by host recognition of 'PAMPS', or pathogen-associated molecular patterns. Saito et al. have now identified a conserved poly-uridine motif in the 3´ non-transcribed region of the hepatitis C virus genome as the relevant PAMP for detection by the RNA helicase RIG-I, a protein previously shown to have an essential function in double-stranded RNA-induced innate antiviral responses.

Suggested Citation

  • Takeshi Saito & David M. Owen & Fuguo Jiang & Joseph Marcotrigiano & Michael Gale Jr., 2008. "Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA," Nature, Nature, vol. 454(7203), pages 523-527, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07106
    DOI: 10.1038/nature07106
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