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Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons

Author

Listed:
  • Simon G. Sprecher

    (Center for Developmental Genetics, New York University, 1090 Silver Center, 100 Washington Square East, New York, New York 10003-6688, USA)

  • Claude Desplan

    (Center for Developmental Genetics, New York University, 1090 Silver Center, 100 Washington Square East, New York, New York 10003-6688, USA)

Abstract

Differentiated sensory neurons that switch fate Sensory neurons, once they have completed their embryonic development, usually maintain robust expression of specific sensory receptor genes, for example light colour-sensitive pigments. In this study, Simon Sprecher and Claude Desplan show that blue-sensitive (Rh5) neurons in the fruitfly's larval eye switch fate — and switch pigment — during metamorphosis to become green sensitive (Rh6) and form the adult eyelets, small organs on the top of the fly's head, which reset its circadian clock. The work opens the way to the genetic investigation of gene regulatory mechanisms controlling such rare fate-switching events in post-mitotic neurons.

Suggested Citation

  • Simon G. Sprecher & Claude Desplan, 2008. "Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons," Nature, Nature, vol. 454(7203), pages 533-537, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07062
    DOI: 10.1038/nature07062
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