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Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

Author

Listed:
  • Kihoon Lee

    (University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA)

  • Yu Zhang

    (University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA)

  • Sang Eun Lee

    (University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA)

Abstract

Tel-tail signs of chromosome healing Chromosomal translocations are characteristic of some leukaemias and childhood sarcomas. They are thought to be initiated by DNA breaks that are repaired by non-homologous end joining, a process which links, or 'heals', any two broken ends, regardless of whether they arose from the same double-strand break. In this work, Lee et al. have devised a system to replicate this type of translocation event in yeast. Using this system they find that Tel1, the yeast homologue of the ATM kinase which is mutated in ataxia-telangiectasia, is a key factor in suppressing non-homologous end joining of interchromosomal DNA ends.

Suggested Citation

  • Kihoon Lee & Yu Zhang & Sang Eun Lee, 2008. "Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations," Nature, Nature, vol. 454(7203), pages 543-546, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07054
    DOI: 10.1038/nature07054
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