IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v454y2008i7202d10.1038_nature07021.html
   My bibliography  Save this article

IL-21 and TGF-β are required for differentiation of human TH17 cells

Author

Listed:
  • Li Yang

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • David E. Anderson

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Clare Baecher-Allan

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • William D. Hastings

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Estelle Bettelli

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Mohamed Oukka

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Vijay K. Kuchroo

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • David A. Hafler

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Cytokines involved in TH17 cell differentiation TH17 cells (a subset of interleukin (IL)-17-producing T helper cells) are thought to contribute to the pathogenesis of a number of human autoimmune diseases. This study examines which cytokines are required for the production of IL-17A by memory and naive human CD4 T cells. The data demonstrate that transforming growth factor-β (TGF-β) is critical for the differentiation of TH17 cells from highly purified naive CD4+ T cells, but not necessary for induction of IL-17 from committed memory CD4+ T cells.

Suggested Citation

  • Li Yang & David E. Anderson & Clare Baecher-Allan & William D. Hastings & Estelle Bettelli & Mohamed Oukka & Vijay K. Kuchroo & David A. Hafler, 2008. "IL-21 and TGF-β are required for differentiation of human TH17 cells," Nature, Nature, vol. 454(7202), pages 350-352, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7202:d:10.1038_nature07021
    DOI: 10.1038/nature07021
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07021
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07021?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:454:y:2008:i:7202:d:10.1038_nature07021. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.