IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v454y2008i7201d10.1038_nature07019.html
   My bibliography  Save this article

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

Author

Listed:
  • Aline Bozec

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Present addresses: Spanish National Cancer Research Centre (C.N.I.O.), C/ Melchor Fernández Almagro, 3, E-28029 Madrid, Spain (A.B., L.B., E.F.W.); Ludwig Boltzmann Institute for Cancer Research, Währinger Strasse 13a, A-1090 Vienna, Austria (R.E.).)

  • Latifa Bakiri

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Present addresses: Spanish National Cancer Research Centre (C.N.I.O.), C/ Melchor Fernández Almagro, 3, E-28029 Madrid, Spain (A.B., L.B., E.F.W.); Ludwig Boltzmann Institute for Cancer Research, Währinger Strasse 13a, A-1090 Vienna, Austria (R.E.).)

  • Astrid Hoebertz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Robert Eferl

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Present addresses: Spanish National Cancer Research Centre (C.N.I.O.), C/ Melchor Fernández Almagro, 3, E-28029 Madrid, Spain (A.B., L.B., E.F.W.); Ludwig Boltzmann Institute for Cancer Research, Währinger Strasse 13a, A-1090 Vienna, Austria (R.E.).)

  • Arndt F. Schilling

    (Center for Biomechanics and Skeletal Biology, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany)

  • Vukoslav Komnenovic

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Harald Scheuch

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Matthias Priemel

    (Center for Biomechanics and Skeletal Biology, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany)

  • Colin L. Stewart

    (Developmental and Regenerative Biology Laboratory, Institute of Medical Biology (I.M.B.), 8A Biomedical Grove, #06-06 Immunos, 138648 Singapore)

  • Michael Amling

    (Center for Biomechanics and Skeletal Biology, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany)

  • Erwin F. Wagner

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Present addresses: Spanish National Cancer Research Centre (C.N.I.O.), C/ Melchor Fernández Almagro, 3, E-28029 Madrid, Spain (A.B., L.B., E.F.W.); Ludwig Boltzmann Institute for Cancer Research, Währinger Strasse 13a, A-1090 Vienna, Austria (R.E.).)

Abstract

Bone-destructive diseases: The role of osteoclast size Osteoclasts are cells that resorb bone. Too many of them, and osteoporosis — a common metabolic disorder of the skeleton — can result, as well as several other diseases. Although the protein c-Fos plays an essential part in the formation of osteoclasts, the specific role of related protein Fra-2 has been unclear. Here Fra-2 is shown to control osteoclast survival and size in newborn mice, in a process involving a novel biochemical pathway that includes the protein LIF as well as hypoxia. The Fra-2 exerts this effect from within the placenta, rather than the embryo itself. This suggests that placental-induced hypoxia during embryogenesis leads to giant osteoclast formation in young pups. This work provides the basis for developing new strategies aimed at manipulating osteoclast activity, improving disease diagnostics and understanding the pathogenesis of bone loss syndromes.

Suggested Citation

  • Aline Bozec & Latifa Bakiri & Astrid Hoebertz & Robert Eferl & Arndt F. Schilling & Vukoslav Komnenovic & Harald Scheuch & Matthias Priemel & Colin L. Stewart & Michael Amling & Erwin F. Wagner, 2008. "Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia," Nature, Nature, vol. 454(7201), pages 221-225, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7201:d:10.1038_nature07019
    DOI: 10.1038/nature07019
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07019
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07019?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:454:y:2008:i:7201:d:10.1038_nature07019. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.