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Imaging the biogenesis of individual HIV-1 virions in live cells

Author

Listed:
  • Nolwenn Jouvenet

    (Aaron Diamond AIDS Research Center,
    Laboratory of Retrovirology, and,)

  • Paul D. Bieniasz

    (Aaron Diamond AIDS Research Center,
    Laboratory of Retrovirology, and,)

  • Sanford M. Simon

    (Laboratory of Cellular Biophysics, The Rockefeller University, New York, New York 10065, USA)

Abstract

HIV/AIDS: Movie of virus particle assembly For the first time, the assembly of a virus particle has been observed directly in live cells. Using techniques based on total internal reflection fluorescence microscopy, and live HeLa cells expressing fluorescent protein-tagged derivatives of Gag, the major structural component of HIV-1, individual HIV-1 virus particles were observed in real time. The resulting movies resolve a controversy over where in the cells HIV-1 assembly occurs — the virions appear individually at the plasma membrane and are assembled in about 5 or 6 minutes.

Suggested Citation

  • Nolwenn Jouvenet & Paul D. Bieniasz & Sanford M. Simon, 2008. "Imaging the biogenesis of individual HIV-1 virions in live cells," Nature, Nature, vol. 454(7201), pages 236-240, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7201:d:10.1038_nature06998
    DOI: 10.1038/nature06998
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    Cited by:

    1. Jing Jin & Nathan M Sherer & Gisela Heidecker & David Derse & Walther Mothes, 2009. "Assembly of the Murine Leukemia Virus Is Directed towards Sites of Cell–Cell Contact," PLOS Biology, Public Library of Science, vol. 7(7), pages 1-15, July.
    2. Michael D Tomasini & Daniel S Johnson & Joshua S Mincer & Sanford M Simon, 2018. "Modeling the dynamics and kinetics of HIV-1 Gag during viral assembly," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-31, April.

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