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Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Author

Listed:
  • Kelly L. Conrad

    (Department of Neuroscience and,)

  • Kuei Y. Tseng

    (Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA)

  • Jamie L. Uejima

    (Behavioral Neuroscience Branch, IRP/NIDA/NIH, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA)

  • Jeremy M. Reimers

    (Department of Neuroscience and,)

  • Li-Jun Heng

    (Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA)

  • Yavin Shaham

    (Behavioral Neuroscience Branch, IRP/NIDA/NIH, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA)

  • Michela Marinelli

    (Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA)

  • Marina E. Wolf

    (Department of Neuroscience and,)

Abstract

The craving for cocaine Relapse to cocaine use after abstinence is often induced by drug-associated cues, but what mediates this reactivity of neurons to these cues is not fully understood. Cocaine-seeking depends on activation of glutamatergic AMPA receptors in the nucleus accumbens. Conrad et al. show that the number of AMPA receptors increases during abstinence in rats, and that the new receptors have a higher conductance. The additional receptors were critical for the increased reactivity of nucleus accumbens neurons to cocaine-related cues, suggesting a novel target for treating relapse.

Suggested Citation

  • Kelly L. Conrad & Kuei Y. Tseng & Jamie L. Uejima & Jeremy M. Reimers & Li-Jun Heng & Yavin Shaham & Michela Marinelli & Marina E. Wolf, 2008. "Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving," Nature, Nature, vol. 454(7200), pages 118-121, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7200:d:10.1038_nature06995
    DOI: 10.1038/nature06995
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