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Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

Author

Listed:
  • Xiangting Wang

    (Howard Hughes Medical Institute,
    Molecular Pathology Graduate Program,)

  • Shigeki Arai

    (Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama-Ken, Mail code 350-1241, Japan)

  • Xiaoyuan Song

    (Howard Hughes Medical Institute,)

  • Donna Reichart

    (and)

  • Kun Du

    (Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama-Ken, Mail code 350-1241, Japan)

  • Gabriel Pascual

    (and
    School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Paul Tempst

    (Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute,
    School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Christopher K. Glass

    (and
    School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Riki Kurokawa

    (Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama-Ken, Mail code 350-1241, Japan)

Abstract

Gene transcription: Inhibition by non-coding RNAs DNA damage induces expression of a non-coding RNA, which acts like a ligand to recruit a specific RNA-binding protein, TLS. This protein in turn represses transcription of the gene to which the non-coding RNA is tethered by inhibiting a histone acetyltransferase coactivator. These data suggest that non-coding RNAs induced in regulatory regions of transcription units recruit and modulate the activities of distinct classes of RNA binding co-regulators in response to specific signalling programs, providing an unexpected RNA-based strategy to integrate transcriptional programs.

Suggested Citation

  • Xiangting Wang & Shigeki Arai & Xiaoyuan Song & Donna Reichart & Kun Du & Gabriel Pascual & Paul Tempst & Michael G. Rosenfeld & Christopher K. Glass & Riki Kurokawa, 2008. "Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription," Nature, Nature, vol. 454(7200), pages 126-130, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7200:d:10.1038_nature06992
    DOI: 10.1038/nature06992
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