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Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution

Author

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  • Brian T. Wilhelm

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

  • Samuel Marguerat

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

  • Stephen Watt

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

  • Falk Schubert

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

  • Valerie Wood

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Ian Goodhead

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

  • Christopher J. Penkett

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

  • Jane Rogers

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Jürg Bähler

    (Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Present addresses: Institut de Recherche en Immunologie et en Cancérologie (IRIC), Montreal, H3C 3J7, Canada (B.T.W.); Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK (S.M., S.W., F.S. and J.B); School of Biological Sciences, University of Liverpool, L69 7ZB, UK (I.G.); EMBL-European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK (C.J.P.).)

Abstract

Genome expression: A hive of activity Until recently, it was thought that much of a genome sequence is silent for much of the time. Now a study in the fission yeast Schizosaccharomyces pombe, using recently developed DNA sequencing technologies, shows that almost all of the yeast genome is genetically active. More than 90% of the genome is transcribed into RNA, including more than 450 newly discovered transcripts, many of them non-coding, with regulatory or other unknown roles.

Suggested Citation

  • Brian T. Wilhelm & Samuel Marguerat & Stephen Watt & Falk Schubert & Valerie Wood & Ian Goodhead & Christopher J. Penkett & Jane Rogers & Jürg Bähler, 2008. "Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution," Nature, Nature, vol. 453(7199), pages 1239-1243, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7199:d:10.1038_nature07002
    DOI: 10.1038/nature07002
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    Cited by:

    1. Michelle T Dimon & Katherine Sorber & Joseph L DeRisi, 2010. "HMMSplicer: A Tool for Efficient and Sensitive Discovery of Known and Novel Splice Junctions in RNA-Seq Data," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-16, November.

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