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Translation factors promote the formation of two states of the closed-loop mRNP

Author

Listed:
  • Nadia Amrani

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA)

  • Shubhendu Ghosh

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA)

  • David A. Mangus

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA)

  • Allan Jacobson

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA)

Abstract

Closed-loop mRNP: The role of translation factors The 5′ and 3′ ends of eukaryotic mRNAs are brought together to form a closed loop. This involves the cap structure at the 5′ end of the mRNA, and the poly(A) tail that comprises the 3′ end. This loop structure helps stabilize the mRNA and facilitates translation. In this work, Amrani et al. find that there are two distinct closed loops formed in yeast, which differ in the form of the ribosome bound. The form containing the full ribosome is also surprisingly associated with termination factors, even though termination is not required for loop formation.

Suggested Citation

  • Nadia Amrani & Shubhendu Ghosh & David A. Mangus & Allan Jacobson, 2008. "Translation factors promote the formation of two states of the closed-loop mRNP," Nature, Nature, vol. 453(7199), pages 1276-1280, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7199:d:10.1038_nature06974
    DOI: 10.1038/nature06974
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