IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v453y2008i7198d10.1038_nature06973.html
   My bibliography  Save this article

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

Author

Listed:
  • Helene R. McMurray

    (Department of Biomedical Genetics,)

  • Erik R. Sampson

    (Department of Biomedical Genetics,)

  • George Compitello

    (Department of Biomedical Genetics,)

  • Conan Kinsey

    (Department of Biomedical Genetics,)

  • Laurel Newman

    (Department of Biomedical Genetics,)

  • Bradley Smith

    (Department of Biomedical Genetics,)

  • Shaw-Ree Chen

    (Department of Biomedical Genetics,)

  • Lev Klebanov

    (Department of Biostatistics and Computational Biology,
    Charles University, Sokolovska 83, Praha-8, CZ-18675, Czech Republic)

  • Peter Salzman

    (Department of Biostatistics and Computational Biology,)

  • Andrei Yakovlev

    (Department of Biostatistics and Computational Biology,
    James P. Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA)

  • Hartmut Land

    (Department of Biomedical Genetics,
    James P. Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA)

Abstract

Cancer-inducing genes: Role of Ras/p53 synergy Oncogenes and/or the loss of tumour suppressor genes generally cooperate with each other in transforming cells into cancer cells. A new study identifies a list of genes synergistically regulated by the Ras oncogene and loss of the p53 tumour suppressor gene. Many of these genes are essential for tumour formation in vivo, whereas few of the genes regulated by either Ras or p53 alone are important. This establishes a new approach to finding genes important in tumorigenesis that may also represent novel targets for tumour therapy.

Suggested Citation

  • Helene R. McMurray & Erik R. Sampson & George Compitello & Conan Kinsey & Laurel Newman & Bradley Smith & Shaw-Ree Chen & Lev Klebanov & Peter Salzman & Andrei Yakovlev & Hartmut Land, 2008. "Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype," Nature, Nature, vol. 453(7198), pages 1112-1116, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7198:d:10.1038_nature06973
    DOI: 10.1038/nature06973
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06973
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06973?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:453:y:2008:i:7198:d:10.1038_nature06973. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.