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Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Author

Listed:
  • Keizo Kanasaki

    (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Kristin Palmsten

    (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Hikaru Sugimoto

    (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Shakil Ahmad

    (The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Birmingham Women’s Hospital, Edgbaston, Birmingham B15 2TG, UK)

  • Yuki Hamano

    (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Liang Xie

    (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Samuel Parry

    (University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6142, USA)

  • Hellmut G. Augustin

    (Medical Faculty Mannheim, University of Heidelberg, and German Cancer Research Center Heidelberg)

  • Vincent H. Gattone

    (Indiana University School of Medicine, Indianapolis, Indiana 46202, USA)

  • Judah Folkman

    (Program in Vascular Biology, The Children’s Hospital Boston, Boston, Massachusetts 02215, USA)

  • Jerome F. Strauss

    (School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA)

  • Raghu Kalluri

    (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Boston, Massachusetts 02215, USA
    Harvard Medical School, Boston, Massachusetts 02215, USA)

Abstract

Pre-ecalmpsia: Prevention by 2-methoxyoestradiol Pre-eclampsia can be a serious complication during pregnancy. Kanasaki et al. now show that mice lacking the enzyme catechol-O-methyltransferase (COMT) develop a pre-eclampsia-like syndrome which can be ameliorated by 2-methoxyoestradiol (2-ME), which is produced by COMT. Although this novel mouse model doesn't completely recapitulate pre-eclampsia seen in women, the authors find that the levels of COMT and 2-ME are diminished in women with pre-eclampsia, suggesting that 2-ME might therefore be of therapeutic value.

Suggested Citation

  • Keizo Kanasaki & Kristin Palmsten & Hikaru Sugimoto & Shakil Ahmad & Yuki Hamano & Liang Xie & Samuel Parry & Hellmut G. Augustin & Vincent H. Gattone & Judah Folkman & Jerome F. Strauss & Raghu Kallu, 2008. "Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia," Nature, Nature, vol. 453(7198), pages 1117-1121, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7198:d:10.1038_nature06951
    DOI: 10.1038/nature06951
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