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A phosphatase cascade by which rewarding stimuli control nucleosomal response

Author

Listed:
  • Alexandre Stipanovich

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Emmanuel Valjent

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Miriam Matamales

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Akinori Nishi

    (Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA)

  • Jung-Hyuck Ahn

    (Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA)

  • Matthieu Maroteaux

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Jesus Bertran-Gonzalez

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Karen Brami-Cherrier

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Hervé Enslen

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Anne-Gaëlle Corbillé

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Odile Filhol

    (Inserm, U873, CEA, 38054 Grenoble, France)

  • Angus C. Nairn

    (Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Yale University School of Medicine, New Haven, Connecticut 06508, USA)

  • Paul Greengard

    (Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA)

  • Denis Hervé

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

  • Jean-Antoine Girault

    (Inserm, UMR-S 839, 75005 Paris, France
    Université Pierre et Marie Curie (UPMC)
    Institut du Fer à Moulin)

Abstract

Appetite and drug addiction Disruptions in dopamine signalling have been implicated in psychiatric disorders, such as schizophrenia and drug addiction. The phosphoprotein DARPP-32 is a prominent mediator of dopamine signalling in the striatum, a part of the brain where dopaminergic activation has been linked to reward and learning. Now a novel signal transduction cascade involving nuclear accumulation of DARPP-32 has been discovered, induced by both drugs of abuse and natural stimuli such as food. Disruption of this cascade alters the behavioural effects of the drugs and decreases motivation for food, suggesting a role for this mechanism in the in vivo actions of dopamine signalling.

Suggested Citation

  • Alexandre Stipanovich & Emmanuel Valjent & Miriam Matamales & Akinori Nishi & Jung-Hyuck Ahn & Matthieu Maroteaux & Jesus Bertran-Gonzalez & Karen Brami-Cherrier & Hervé Enslen & Anne-Gaëlle Corbillé , 2008. "A phosphatase cascade by which rewarding stimuli control nucleosomal response," Nature, Nature, vol. 453(7197), pages 879-884, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06994
    DOI: 10.1038/nature06994
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