IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v453y2008i7197d10.1038_nature06975.html
   My bibliography  Save this article

Towards a transgenic model of Huntington’s disease in a non-human primate

Author

Listed:
  • Shang-Hsun Yang

    (Yerkes National Primate Research Center,
    Department of Human Genetics,
    Genetics and Molecular Biology Program,)

  • Pei-Hsun Cheng

    (Yerkes National Primate Research Center,
    Department of Human Genetics,)

  • Heather Banta

    (Yerkes National Primate Research Center,)

  • Karolina Piotrowska-Nitsche

    (Yerkes National Primate Research Center,
    Department of Human Genetics,
    Institute of Genetics and Animal Breeding, Polish Academy of Sciences)

  • Jin-Jing Yang

    (Yerkes National Primate Research Center,
    Department of Human Genetics,)

  • Eric C. H. Cheng

    (Yerkes National Primate Research Center,
    Department of Human Genetics,)

  • Brooke Snyder

    (Yerkes National Primate Research Center,
    Department of Human Genetics,)

  • Katherine Larkin

    (Yerkes National Primate Research Center,)

  • Jun Liu

    (Yerkes National Primate Research Center,
    Department of Human Genetics,
    Neuroscience Program,)

  • Jack Orkin

    (Yerkes National Primate Research Center,)

  • Zhi-Hui Fang

    (Department of Human Genetics,)

  • Yoland Smith

    (Yerkes National Primate Research Center,
    Neuroscience Program,
    Department of Neurology,)

  • Jocelyne Bachevalier

    (Yerkes National Primate Research Center,
    Department of Psychology,
    Emory University, Atlanta, Georgia 30329, USA)

  • Stuart M. Zola

    (Yerkes National Primate Research Center,
    Neuroscience Program,
    Emory University, Atlanta, Georgia 30329, USA
    Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA)

  • Shi-Hua Li

    (Department of Human Genetics,)

  • Xiao-Jiang Li

    (Department of Human Genetics,
    Genetics and Molecular Biology Program,
    Neuroscience Program,)

  • Anthony W. S. Chan

    (Yerkes National Primate Research Center,
    Department of Human Genetics,
    Genetics and Molecular Biology Program,
    Neuroscience Program,)

Abstract

Huntington's disease: Model answers Huntington's disease is a severely disabling and lethal neurodegenerative disorder. The development of a non-human primate model for the disease would be invaluable in understanding its pathology and in developing therapeutic strategies, and this paper reports a significant step towards that goal is reported in this issue. Transgenic rhesus macaque monkeys that express the first exon of the polyglutamine-expanded human huntingtin gene develop key features of Huntington's disease, including dystonia and chorea. The data suggest that it will be feasible to generate non-human primate models for Huntington's disease and possibly for other neurodegenerative disorders, where rodent models may not reflect the brain changes and behavioural features of the human disease.

Suggested Citation

  • Shang-Hsun Yang & Pei-Hsun Cheng & Heather Banta & Karolina Piotrowska-Nitsche & Jin-Jing Yang & Eric C. H. Cheng & Brooke Snyder & Katherine Larkin & Jun Liu & Jack Orkin & Zhi-Hui Fang & Yoland Smit, 2008. "Towards a transgenic model of Huntington’s disease in a non-human primate," Nature, Nature, vol. 453(7197), pages 921-924, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06975
    DOI: 10.1038/nature06975
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06975
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06975?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06975. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.