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Global control of cell-cycle transcription by coupled CDK and network oscillators

Author

Listed:
  • David A. Orlando

    (Department of Biology,
    Program in Computational Biology and Bioinformatics,)

  • Charles Y. Lin

    (Department of Biology,)

  • Allister Bernard

    (Department of Computer Science,)

  • Jean Y. Wang

    (Department of Biology,)

  • Joshua E. S. Socolar

    (and)

  • Edwin S. Iversen

    (Duke University, Durham, North Carolina 27708, USA)

  • Alexander J. Hartemink

    (Department of Computer Science,)

  • Steven B. Haase

    (Department of Biology,)

Abstract

The cell cycle: More regulators to look for During the cell cycle, many genes are transcribed in a periodic manner. A new study in Saccharomyces cerevisiae shows that a significant proportion of these genes continue to cycle in the absence of the major cell cycle regulatory cyclin/CDK complexes that control the G1-S transition. This suggests the existence of additional period regulators responsible for the periodic transcription of genes during the cell cycle.

Suggested Citation

  • David A. Orlando & Charles Y. Lin & Allister Bernard & Jean Y. Wang & Joshua E. S. Socolar & Edwin S. Iversen & Alexander J. Hartemink & Steven B. Haase, 2008. "Global control of cell-cycle transcription by coupled CDK and network oscillators," Nature, Nature, vol. 453(7197), pages 944-947, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06955
    DOI: 10.1038/nature06955
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    Cited by:

    1. Alessandro Romanel & Lars Juhl Jensen & Luca Cardelli & Attila Csikász-Nagy, 2012. "Transcriptional Regulation Is a Major Controller of Cell Cycle Transition Dynamics," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-9, January.
    2. Karan Mangla & David L Dill & Mark A Horowitz, 2010. "Timing Robustness in the Budding and Fission Yeast Cell Cycles," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-7, February.

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