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The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

Author

Listed:
  • Katsutomo Okamura

    (Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA)

  • Wei-Jen Chung

    (Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA)

  • J. Graham Ruby

    (Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA)

  • Huili Guo

    (Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA)

  • David P. Bartel

    (Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA)

  • Eric C. Lai

    (Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA)

Abstract

Endo-siRNAs in Drosophila Short interfering RNAs (siRNAs) target cleavage of mRNAs with complementary sequences. In this work, Okamura et al. show that the Drosophila genome encodes endogenous siRNAs. Derived from long RNA hairpin genes, these siRNAs downregulate protein expression. Their processing pathway from the hairpin into the mature 21-nucleodite long siRNA involves factors of two pathways thought to be distinct.

Suggested Citation

  • Katsutomo Okamura & Wei-Jen Chung & J. Graham Ruby & Huili Guo & David P. Bartel & Eric C. Lai, 2008. "The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs," Nature, Nature, vol. 453(7196), pages 803-806, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7196:d:10.1038_nature07015
    DOI: 10.1038/nature07015
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