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NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Author

Listed:
  • Jordi Rius

    (Laboratory of Gene Regulation and Signal Transduction,
    Department of Pharmacology,
    Department of Pathology,)

  • Monica Guma

    (Laboratory of Gene Regulation and Signal Transduction,
    Department of Pharmacology,
    Department of Pathology,)

  • Christian Schachtrup

    (Department of Pharmacology,)

  • Katerina Akassoglou

    (Department of Pharmacology,)

  • Annelies S. Zinkernagel

    (School of Medicine)

  • Victor Nizet

    (School of Medicine
    Skaggs School of Pharmacy and Pharmaceutical Sciences, and,)

  • Randall S. Johnson

    (Molecular Biology Section, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Gabriel G. Haddad

    (School of Medicine)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction,
    Department of Pharmacology,
    Department of Pathology,)

Abstract

Hypoxia and innate immunity: An old alliance Several lines of evidence have hinted at a possible connection between two evolutionarily ancient cellular defence mechanisms — innate immunity and the hypoxic response. Now that link has been clearly demonstrated with the discovery that a single protein is essential to both responses. The cellular response to hypoxia is triggered by low oxygen levels and controlled by hypoxia-inducible factor-1α (HIF-1α). The new work shows that HIF-1α transcription is regulated by the transcription factor NF-κB — more usually encountered as the master regulator of the innate immune response.

Suggested Citation

  • Jordi Rius & Monica Guma & Christian Schachtrup & Katerina Akassoglou & Annelies S. Zinkernagel & Victor Nizet & Randall S. Johnson & Gabriel G. Haddad & Michael Karin, 2008. "NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α," Nature, Nature, vol. 453(7196), pages 807-811, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7196:d:10.1038_nature06905
    DOI: 10.1038/nature06905
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