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CLEC5A is critical for dengue-virus-induced lethal disease

Author

Listed:
  • Szu-Ting Chen

    (National Yang-Ming University)

  • Yi-Ling Lin

    (Institute of Biomedical Sciences, and,
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan)

  • Ming-Ting Huang

    (National Yang-Ming University)

  • Ming-Fang Wu

    (National Yang-Ming University)

  • Shih-Chin Cheng

    (National Yang-Ming University)

  • Huan-Yao Lei

    (National Cheng Kung University)

  • Chien-Kuo Lee

    (Institute of Immunology, National Taiwan University)

  • Tzyy-Wen Chiou

    (National Dong Hwa University)

  • Chi-Huey Wong

    (Genomics Research Center, Academia Sinica, Taipei 115, Taiwan)

  • Shie-Liang Hsieh

    (National Yang-Ming University
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    Immunology Research Center, National Yang-Ming University & Taipei Veterans General Hospital)

Abstract

Dengue virus: Reading the signals Dengue haemorrhagic fever is transmitted by the bite of a mosquito infected with dengue virus. It infects more that 50 million people a year and causes some 20,000 deaths, but at present there are no vaccines or therapies specific for the virus. The identification of the host proteins targeted by the virus and the signalling pathways responsible for controlling inflammation and antiviral immunity are essential for the development of therapeutic strategies. Szu-Ting Chen et al. have made a step towards that goal with the discovery that dengue virus interacts with the C-type lectin CLEC5A. The interaction promotes the production of pro-inflammatory cytokines and contributes to lethal disease in a mouse model.

Suggested Citation

  • Szu-Ting Chen & Yi-Ling Lin & Ming-Ting Huang & Ming-Fang Wu & Shih-Chin Cheng & Huan-Yao Lei & Chien-Kuo Lee & Tzyy-Wen Chiou & Chi-Huey Wong & Shie-Liang Hsieh, 2008. "CLEC5A is critical for dengue-virus-induced lethal disease," Nature, Nature, vol. 453(7195), pages 672-676, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7195:d:10.1038_nature07013
    DOI: 10.1038/nature07013
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