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Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Author

Listed:
  • Yi Guo

    (Department of Biochemistry and Biophysics,
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA)

  • Tobias C. Walther

    (Department of Biochemistry and Biophysics,
    Max-Planck Institute of Biochemistry)

  • Meghana Rao

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA)

  • Nico Stuurman

    (and)

  • Gohta Goshima

    (and
    Present address: Institute for Advanced Research, Nagoya University, 464-8601 Nagoya, Japan.)

  • Koji Terayama

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA)

  • Jinny S. Wong

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA)

  • Ronald D. Vale

    (and
    Howard Hughes Medical Institute, University of California, San Francisco, California 94158-2517, USA)

  • Peter Walter

    (Department of Biochemistry and Biophysics,
    Howard Hughes Medical Institute, University of California, San Francisco, California 94158-2517, USA)

  • Robert V. Farese

    (Department of Biochemistry and Biophysics,
    University of California, San Francisco, California 94158, USA
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA)

Abstract

Celluar lipids: Trouble in store Lipid droplets are found in nearly all eukaryotic cells and contain neutral lipids such as triacylglycerols and sterol esters. There is rapidly growing interest in the cell biology of lipid storage, largely due to the central role that these processes play in obesity and related metabolic diseases. Guo et al. have performed a genome-wide RNA interference screen in Drosophila cells and identify genes involved in lipid droplet formation and utilization. About 1.5% of all genes are involved in these processes.

Suggested Citation

  • Yi Guo & Tobias C. Walther & Meghana Rao & Nico Stuurman & Gohta Goshima & Koji Terayama & Jinny S. Wong & Ronald D. Vale & Peter Walter & Robert V. Farese, 2008. "Functional genomic screen reveals genes involved in lipid-droplet formation and utilization," Nature, Nature, vol. 453(7195), pages 657-661, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7195:d:10.1038_nature06928
    DOI: 10.1038/nature06928
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