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HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Author

Listed:
  • Nabieh Ayoub

    (The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK)

  • Anand D. Jeyasekharan

    (The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK)

  • Juan A. Bernal

    (The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK)

  • Ashok R. Venkitaraman

    (The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK)

Abstract

DNA repair: Mobilizing chromatin factors The earliest known response to chromosomal DNA breakage is the phosphorylation of the histone H2AX. Ayoub et al. have now identified a dynamic change in chromatin that promotes this phosphorylation step. DNA breaks swiftly mobilize the chromatin factor HP1-β, and via a previously unrecognized signalling cascade involving a phosphorylation step carried out by casein kinase 2, H2AX becomes phosphorylated and the DNA damage response is under way.

Suggested Citation

  • Nabieh Ayoub & Anand D. Jeyasekharan & Juan A. Bernal & Ashok R. Venkitaraman, 2008. "HP1-β mobilization promotes chromatin changes that initiate the DNA damage response," Nature, Nature, vol. 453(7195), pages 682-686, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7195:d:10.1038_nature06875
    DOI: 10.1038/nature06875
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