IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v453y2008i7194d10.1038_nature06933.html
   My bibliography  Save this article

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Author

Listed:
  • Wei Guo

    (Department of Molecular and Medical Pharmacology,)

  • Joseph L. Lasky

    (Department of Pediatric Hematology/Oncology,)

  • Chun-Ju Chang

    (Department of Molecular and Medical Pharmacology,)

  • Sherly Mosessian

    (Department of Molecular and Medical Pharmacology,)

  • Xiaoman Lewis

    (Department of Molecular and Medical Pharmacology,)

  • Yun Xiao

    (University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA)

  • Jennifer E. Yeh

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • James Y. Chen

    (Department of Molecular and Medical Pharmacology,)

  • M. Luisa Iruela-Arispe

    (and)

  • Marileila Varella-Garcia

    (University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA)

  • Hong Wu

    (Department of Molecular and Medical Pharmacology,
    Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Cellular and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA)

Abstract

Cancer model: Pten deletion mimics acute T lymphoblastic leukaemia A new leukaemia model has been established in mice by deleting the Pten tumour suppressor gene in fetal liver haematopoietic stem cells. The mice develop a myeloproliferative disorder that can lead to acute T lymphoblastic leukaemia. Progression of the condition is driven by leukaemia stem cells that require beta-catenin and incorporate a translocation that leads to overexpression of the c-myc oncogene, similar to findings in human acute T lymphoblastic leukaemia. The study illustrates how multiple genetic alterations can dictate hyperproliferative disorders and the progression to cancer.

Suggested Citation

  • Wei Guo & Joseph L. Lasky & Chun-Ju Chang & Sherly Mosessian & Xiaoman Lewis & Yun Xiao & Jennifer E. Yeh & James Y. Chen & M. Luisa Iruela-Arispe & Marileila Varella-Garcia & Hong Wu, 2008. "Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation," Nature, Nature, vol. 453(7194), pages 529-533, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06933
    DOI: 10.1038/nature06933
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06933
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06933?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06933. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.