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A chemical approach to stem-cell biology and regenerative medicine

Author

Listed:
  • Yue Xu

    (The Scripps Research Institute)

  • Yan Shi

    (The Scripps Research Institute)

  • Sheng Ding

    (The Scripps Research Institute)

Abstract

An improved understanding of stem-cell and regenerative biology, as well as a better control of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries. Chemical approaches are starting to have an increasingly important role in this young field. Attention has focused on chemical approaches that allow the precise manipulation of cells in vitro to obtain homogeneous cell types for cell-based therapies. Another promising approach is the development of conventional chemical and biological therapeutics to stimulate endogenous cells to regenerate. Such therapeutics can act on target cells or their niches in vivo to promote cell survival, proliferation, differentiation, reprogramming and homing.

Suggested Citation

  • Yue Xu & Yan Shi & Sheng Ding, 2008. "A chemical approach to stem-cell biology and regenerative medicine," Nature, Nature, vol. 453(7193), pages 338-344, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7193:d:10.1038_nature07042
    DOI: 10.1038/nature07042
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    Cited by:

    1. Dai Fei Elmer Ker & Lee E Weiss & Silvina N Junkers & Mei Chen & Zhaozheng Yin & Michael F Sandbothe & Seung-il Huh & Sungeun Eom & Ryoma Bise & Elvira Osuna-Highley & Takeo Kanade & Phil G Campbell, 2011. "An Engineered Approach to Stem Cell Culture: Automating the Decision Process for Real-Time Adaptive Subculture of Stem Cells," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-12, November.

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