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Vascular normalization in Rgs5-deficient tumours promotes immune destruction

Author

Listed:
  • Juliana Hamzah

    (Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Western Australia 6000, Australia)

  • Manfred Jugold

    (Juniorgroup Molecular Imaging)

  • Fabian Kiessling

    (Juniorgroup Molecular Imaging)

  • Paul Rigby

    (Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, Western Australia 6000, Australia)

  • Mitali Manzur

    (Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Western Australia 6000, Australia)

  • Hugo H. Marti

    (Institute of Physiology and Pathophysiology, University of Heidelberg)

  • Tamer Rabie

    (Institute of Physiology and Pathophysiology, University of Heidelberg)

  • Sylvia Kaden

    (and)

  • Hermann-Josef Gröne

    (and)

  • Günter J. Hämmerling

    (German Cancer Research Center, 69120 Heidelberg, Germany)

  • Bernd Arnold

    (German Cancer Research Center, 69120 Heidelberg, Germany)

  • Ruth Ganss

    (Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Western Australia 6000, Australia)

Abstract

Anticancer immunotherapy: It's in the blood RGS5, a signalling protein that regulates the activity of G proteins, is shown to be an important regulator of the tumour vasculature. Deletion of Rgs5 leads to normalization of blood vessels of tumours, making them less leaky and improving their coverage with pericytes. As a consequence, more immune cells that can target the tumour cells actually reach the tumour, which enhances the survival of tumour-bearing mice. Thus RGS5 signalling might be a target for anticancer therapy, in particular in combination with approaches that enhance an antitumour immune response.

Suggested Citation

  • Juliana Hamzah & Manfred Jugold & Fabian Kiessling & Paul Rigby & Mitali Manzur & Hugo H. Marti & Tamer Rabie & Sylvia Kaden & Hermann-Josef Gröne & Günter J. Hämmerling & Bernd Arnold & Ruth Ganss, 2008. "Vascular normalization in Rgs5-deficient tumours promotes immune destruction," Nature, Nature, vol. 453(7193), pages 410-414, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7193:d:10.1038_nature06868
    DOI: 10.1038/nature06868
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