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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Author

Listed:
  • Liang Zhou

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,)

  • Jared E. Lopes

    (Immunology Program Benaroya Research Institute Seattle
    and)

  • Mark M. W. Chong

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,)

  • Ivaylo I. Ivanov

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,)

  • Roy Min

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
    Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Gabriel D. Victora

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,)

  • Yuelei Shen

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,)

  • Jianguang Du

    (Immunology Program Benaroya Research Institute Seattle
    and)

  • Yuri P. Rubtsov

    (Howard Hughes Medical Institute, University of Washington Seattle, Washington 98195, USA)

  • Alexander Y. Rudensky

    (Howard Hughes Medical Institute, University of Washington Seattle, Washington 98195, USA)

  • Steven F. Ziegler

    (Immunology Program Benaroya Research Institute Seattle
    and)

  • Dan R. Littman

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
    Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA)

Abstract

The cytokine TFG-β contributes to the differentiation of both regulatory T cells and TH17 cells. This paper shows that in intestinal lamina propria cell lineage differentiation depends on the local TFG-β concentration.

Suggested Citation

  • Liang Zhou & Jared E. Lopes & Mark M. W. Chong & Ivaylo I. Ivanov & Roy Min & Gabriel D. Victora & Yuelei Shen & Jianguang Du & Yuri P. Rubtsov & Alexander Y. Rudensky & Steven F. Ziegler & Dan R. Lit, 2008. "TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function," Nature, Nature, vol. 453(7192), pages 236-240, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7192:d:10.1038_nature06878
    DOI: 10.1038/nature06878
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