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Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision

Author

Listed:
  • Ali D. Güler

    (Johns Hopkins University, Baltimore, Maryland 21218, USA)

  • Jennifer L. Ecker

    (Johns Hopkins University, Baltimore, Maryland 21218, USA)

  • Gurprit S. Lall

    (Faculty of Life Sciences, University of Manchester)

  • Shafiqul Haq

    (and)

  • Cara M. Altimus

    (Johns Hopkins University, Baltimore, Maryland 21218, USA)

  • Hsi-Wen Liao

    (and)

  • Alun R. Barnard

    (Faculty of Life Sciences, University of Manchester)

  • Hugh Cahill

    (and)

  • Tudor C. Badea

    (Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Haiqing Zhao

    (Johns Hopkins University, Baltimore, Maryland 21218, USA)

  • Mark W. Hankins

    (Visual Neuroscience, University of Oxford)

  • David M. Berson

    (Brown University, Providence, Rhode Island 02912, USA)

  • Robert J. Lucas

    (Faculty of Life Sciences, University of Manchester)

  • King-Wai Yau

    (and)

  • Samer Hattar

    (Johns Hopkins University, Baltimore, Maryland 21218, USA)

Abstract

Clock watching The mammalian retina has three types of light-sensing cells: rods, cones and melanopsin-containing cells. Rods and cones are involved in vision but have also been shown to contribute to light entrainment of the circadian clock. Now Güler et al. show that the non-image forming (circadian) role of rods and cones involves signalling via melanopsin-containing cells. This finding implies that people with troubled sleep or seasonal depression could benefit from light detection and melatonin suppression tests even if they are normally sighted.

Suggested Citation

  • Ali D. Güler & Jennifer L. Ecker & Gurprit S. Lall & Shafiqul Haq & Cara M. Altimus & Hsi-Wen Liao & Alun R. Barnard & Hugh Cahill & Tudor C. Badea & Haiqing Zhao & Mark W. Hankins & David M. Berson &, 2008. "Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision," Nature, Nature, vol. 453(7191), pages 102-105, May.
  • Handle: RePEc:nat:nature:v:453:y:2008:i:7191:d:10.1038_nature06829
    DOI: 10.1038/nature06829
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    Cited by:

    1. Cheng Qian & Ying Xin & Cheng Qi & Hui Wang & Bryan C. Dong & Donald J. Zack & Seth Blackshaw & Samer Hattar & Feng-Quan Zhou & Jiang Qian, 2024. "Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Bence Lajos Kolozsvári & Éva Surányi & Zsuzsa Zakarné Aszalós & Vivien Lénárt & Reda Chaker & Géza Vitályos & Mariann Fodor, 2025. "Decades of Night-Shift Work Induce Diurnal Disruption and Corneal Adaptations: Evidence from Pentacam Analysis," IJERPH, MDPI, vol. 22(4), pages 1-12, March.
    3. Ronald A J M Bierings & Marijke C M Gordijn & Nomdo M Jansonius, 2019. "Chronotyping glaucoma patients with the Munich ChronoType Questionnaire: A case-control study," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-11, March.

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