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Integration of growth and specification in chick wing digit-patterning

Author

Listed:
  • Matthew Towers

    (WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Present address: Department of Biology and Biochemistry, University of Bath, Claverton Down Road, Bath BA2 7AY, UK.)

  • Ruth Mahood

    (WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK)

  • Yili Yin

    (WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK)

  • Cheryll Tickle

    (WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Present address: Department of Biology and Biochemistry, University of Bath, Claverton Down Road, Bath BA2 7AY, UK.)

Abstract

An additional function for Sonic hedgehog (Shh) in the limb bud is identified, namely the control of expression of cell cycle regulators, thereby controlling growth and specifying the size of the field in which the digit specification gradient operates. It is found that when Shh signalling was inhibited in chick limb buds, all the digit precursors formed anterior structures. In contrast, when cell proliferation was inhibited, all the anterior structures were lost and all the digit-precursors formed posterior structures.

Suggested Citation

  • Matthew Towers & Ruth Mahood & Yili Yin & Cheryll Tickle, 2008. "Integration of growth and specification in chick wing digit-patterning," Nature, Nature, vol. 452(7189), pages 882-886, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7189:d:10.1038_nature06718
    DOI: 10.1038/nature06718
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