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Chromatin dynamics during epigenetic reprogramming in the mouse germ line

Author

Listed:
  • Petra Hajkova

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Katia Ancelin

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Present address: LBMC/UMR 5665, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364 LYON Cedex 07, France.)

  • Tanja Waldmann

    (Max-Planck-Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany)

  • Nicolas Lacoste

    (CNRS/Institute Curie, 26 rue d’Ulm, 75248 Paris cedex 05, France)

  • Ulrike C. Lange

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Francesca Cesari

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Caroline Lee

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Genevieve Almouzni

    (CNRS/Institute Curie, 26 rue d’Ulm, 75248 Paris cedex 05, France)

  • Robert Schneider

    (Max-Planck-Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany)

  • M. Azim Surani

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

Abstract

Chromatin changes are examined in developing primordial germ cells during the time when the cells undergo a reprogramming step involving loss of DNA methylation and parental imprinting. Reprogramming is found to be linked to changes in histone modifications and to histone replacement through the action of histone chaperones. Histone replacement seems to occur subsequent to DNA demethylation.

Suggested Citation

  • Petra Hajkova & Katia Ancelin & Tanja Waldmann & Nicolas Lacoste & Ulrike C. Lange & Francesca Cesari & Caroline Lee & Genevieve Almouzni & Robert Schneider & M. Azim Surani, 2008. "Chromatin dynamics during epigenetic reprogramming in the mouse germ line," Nature, Nature, vol. 452(7189), pages 877-881, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7189:d:10.1038_nature06714
    DOI: 10.1038/nature06714
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