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Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons

Author

Listed:
  • Takako Makita

    (Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Henry M. Sucov

    (Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA)

  • Cheryl E. Gariepy

    (University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Masashi Yanagisawa

    (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA)

  • David D. Ginty

    (Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

Abstract

This paper implicates vascular-derived endothelins in axonal growth and guidance. It is shown that the origin of smooth muscle cells surrounding the internal and external carotids is different and finds that they preferentially express components of the endothelin ligand-receptor system. The endothelin family member ET3 directs axon extension of a subset of sympathetic neurons to the external carotid artery.

Suggested Citation

  • Takako Makita & Henry M. Sucov & Cheryl E. Gariepy & Masashi Yanagisawa & David D. Ginty, 2008. "Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons," Nature, Nature, vol. 452(7188), pages 759-763, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7188:d:10.1038_nature06859
    DOI: 10.1038/nature06859
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