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Adult T-cell progenitors retain myeloid potential

Author

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  • Haruka Wada

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology
    Present addresses: Division of Bioregulation Research, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki 216-8512, Japan (H.W.); Institute of Molecular Medicine and Genetics, University of Georgia, GA 30602, USA (K.M.).)

  • Kyoko Masuda

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology
    Present addresses: Division of Bioregulation Research, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki 216-8512, Japan (H.W.); Institute of Molecular Medicine and Genetics, University of Georgia, GA 30602, USA (K.M.).)

  • Rumi Satoh

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology)

  • Kiyokazu Kakugawa

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology)

  • Tomokatsu Ikawa

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology)

  • Yoshimoto Katsura

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology
    Advanced Medical Research Center, Nihon University School of Medicine)

  • Hiroshi Kawamoto

    (Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology)

Abstract

Redrawing the blood lines In the current dominant model of haematopoiesis, T cells are thought to arise from lymphoid-restricted common lymphoid progenitors, and myeloid cells (including granulocytes and macrophages, found in bone marrow and spinal cord) from progenitors committed to the myeloid lineage. Two papers in this issue report evidence that contradicts this. Rather, they find a single type of progenitor in adult thymus with both T and myeloid potential. T cells are produced by an early population in the thymus that has lost the ability to produce B cells, but still produces macrophages and cells with T, NK (natural killer) and dendritic cell potential. These results support a model for haematopoiesis where the progenitor cell at the branch point of T and B cell lineages retains macrophage potential.

Suggested Citation

  • Haruka Wada & Kyoko Masuda & Rumi Satoh & Kiyokazu Kakugawa & Tomokatsu Ikawa & Yoshimoto Katsura & Hiroshi Kawamoto, 2008. "Adult T-cell progenitors retain myeloid potential," Nature, Nature, vol. 452(7188), pages 768-772, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7188:d:10.1038_nature06839
    DOI: 10.1038/nature06839
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