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A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Author

Listed:
  • Michael Groll

    (Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, Garching D-85747, Germany)

  • Barbara Schellenberg

    (Zurich–Basel Plant Science Center, Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland)

  • André S. Bachmann

    (Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
    Cell and Molecular Biology Graduate Program, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, Hawaii 96813, USA)

  • Crystal R. Archer

    (Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
    Cell and Molecular Biology Graduate Program, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, Hawaii 96813, USA)

  • Robert Huber

    (Max-Planck-Institut für Biochemie
    School of Biosciences, Cardiff University
    Zentrum für medizinische Biotechnologie, Universität Duisburg-Essen)

  • Tracy K. Powell

    (University of California, 111 Koshland Hall, Berkeley, California 94720-3102, USA)

  • Steven Lindow

    (University of California, 111 Koshland Hall, Berkeley, California 94720-3102, USA)

  • Markus Kaiser

    (Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, D-44227 Dortmund, Germany)

  • Robert Dudler

    (Zurich–Basel Plant Science Center, Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland)

Abstract

Proteasome inhibitors Syringolin A, a virulence factor in Pseudomonas syringae pv. syringae, the cause of bacterial brown spot disease in beans, has been identified as an inhibitor of the eukaryotic proteasome, the cell's central protein degradation system. There is intense interest in proteasome inhibitors as possible drugs against cancer and other diseases. Syringolin A represents a new class of these agents, with considerable therapeutic potential.

Suggested Citation

  • Michael Groll & Barbara Schellenberg & André S. Bachmann & Crystal R. Archer & Robert Huber & Tracy K. Powell & Steven Lindow & Markus Kaiser & Robert Dudler, 2008. "A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism," Nature, Nature, vol. 452(7188), pages 755-758, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7188:d:10.1038_nature06782
    DOI: 10.1038/nature06782
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