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Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

Author

Listed:
  • Frank Niessen

    (Departments of Immunology,)

  • Florence Schaffner

    (Departments of Immunology,)

  • Christian Furlan-Freguia

    (Departments of Immunology,)

  • Rafal Pawlinski

    (Departments of Immunology,)

  • Gourab Bhattacharjee

    (Departments of Immunology,)

  • Jerold Chun

    (Molecular Biology, and,)

  • Claudia K. Derian

    (Johnson & Johnson PRD, Spring House, Pennsylvania 19477, USA)

  • Patricia Andrade-Gordon

    (Johnson & Johnson PRD, Spring House, Pennsylvania 19477, USA)

  • Hugh Rosen

    (Departments of Immunology,
    Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA)

  • Wolfram Ruf

    (Departments of Immunology,)

Abstract

This paper examines the link between coagulation and systematic inflammation, and shows that coagulation proteases signal to dendritic cells by activating PAR1, resulting in activation of the shingolipid signalling component and dissemination of inflammation from the lymph nodes to the lungs.

Suggested Citation

  • Frank Niessen & Florence Schaffner & Christian Furlan-Freguia & Rafal Pawlinski & Gourab Bhattacharjee & Jerold Chun & Claudia K. Derian & Patricia Andrade-Gordon & Hugh Rosen & Wolfram Ruf, 2008. "Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation," Nature, Nature, vol. 452(7187), pages 654-658, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7187:d:10.1038_nature06663
    DOI: 10.1038/nature06663
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