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Memory CD4 T cells emerge from effector T-cell progenitors

Author

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  • Laurie E. Harrington

    (and
    Present address: Department of Cell Biology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294, USA.)

  • Karen M. Janowski

    (and)

  • James R. Oliver

    (and)

  • Allan J. Zajac

    (University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294, USA)

  • Casey T. Weaver

    (and)

Abstract

Naive CD4 and CD8 T cells give rise to effector and long-lived memory T cells after activation by antigen. This paper provides evidence that memory CD4 T cells, similar to their CD8 counterparts, differentiate in a linear fashion from effector cells rather than by an alternative differentiation pathway.

Suggested Citation

  • Laurie E. Harrington & Karen M. Janowski & James R. Oliver & Allan J. Zajac & Casey T. Weaver, 2008. "Memory CD4 T cells emerge from effector T-cell progenitors," Nature, Nature, vol. 452(7185), pages 356-360, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7185:d:10.1038_nature06672
    DOI: 10.1038/nature06672
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