IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v452y2008i7183d10.1038_nature06640.html
   My bibliography  Save this article

Transient cyclical methylation of promoter DNA

Author

Listed:
  • Sara Kangaspeska

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Brenda Stride

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
    Present addresses: Phenex Pharmaceuticals AG, J542N Werksgelände BASF, 67056 Ludwigshafen, Germany (B.S.); Science Foundation Ireland, Wilton Park House, Wilton Place, Dublin 2, Ireland (F.G.).)

  • Raphaël Métivier

    (SPARTE, UMR CNRS, 6026, Université de Rennes I, Bâtiment 13, 35042 Cedex, Rennes, France)

  • Maria Polycarpou-Schwarz

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • David Ibberson

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Richard Paul Carmouche

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Vladimir Benes

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Frank Gannon

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
    Present addresses: Phenex Pharmaceuticals AG, J542N Werksgelände BASF, 67056 Ludwigshafen, Germany (B.S.); Science Foundation Ireland, Wilton Park House, Wilton Place, Dublin 2, Ireland (F.G.).)

  • George Reid

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

Abstract

DNA changes tack Two papers in this issue report cycles of DNA methylation and demethylation of CpG dinucleotides at gene promoters. The findings contrast sharply with the prevailing view of DNA methylation as a stable epigenetic 'mark' capable of transmitting a specific pattern of gene expression through mitosis and into the daughter cells. Métivier et al. observed DNA methylation/demethylation cycles at the pS2 gene promoter during its activation by oestrogen, accompanied by cycling of DNA methyltransferases and other factors. And Kangaspeska et al. report cyclical DNA methylation at five active promoters including pS2 and the oestrogen receptor α.

Suggested Citation

  • Sara Kangaspeska & Brenda Stride & Raphaël Métivier & Maria Polycarpou-Schwarz & David Ibberson & Richard Paul Carmouche & Vladimir Benes & Frank Gannon & George Reid, 2008. "Transient cyclical methylation of promoter DNA," Nature, Nature, vol. 452(7183), pages 112-115, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06640
    DOI: 10.1038/nature06640
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06640
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06640?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ting Jiang & Xue Li & Li Ning & Jiwen Liu, 2019. "Cross-Sectional Survey of Mental Health Risk Factors and Comparison of the Monoamine oxidase A Gene DNA Methylation Level in Different Mental Health Conditions among Oilfield Workers in Xinjiang, Chin," IJERPH, MDPI, vol. 17(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06640. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.