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Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

Author

Listed:
  • Kuan-Ming Chen

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,)

  • Elena Harjes

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,)

  • Phillip J. Gross

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,
    Arnold and Mabel Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA)

  • Amr Fahmy

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Yongjian Lu

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,)

  • Keisuke Shindo

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,
    Arnold and Mabel Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA)

  • Reuben S. Harris

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,
    Arnold and Mabel Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA)

  • Hiroshi Matsuo

    (Molecular Biology and Biophysics
    Institute for Molecular Virology and,)

Abstract

The cellular cytosine deaminase APOBEC3G inhibits replication of HIV lacking the viral protein Vif; here the NMR structure of a mutant form of the catalytic domain of APOBEC3G is reported, and a model for the APOBEC–DNA interaction is proposed.

Suggested Citation

  • Kuan-Ming Chen & Elena Harjes & Phillip J. Gross & Amr Fahmy & Yongjian Lu & Keisuke Shindo & Reuben S. Harris & Hiroshi Matsuo, 2008. "Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G," Nature, Nature, vol. 452(7183), pages 116-119, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06638
    DOI: 10.1038/nature06638
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