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Identification of a serotonin/glutamate receptor complex implicated in psychosis

Author

Listed:
  • Javier González-Maeso

    (Department of Neurology,
    Department of Psychiatry,)

  • Rosalind L. Ang

    (Department of Neurology,)

  • Tony Yuen

    (Department of Neurology,)

  • Pokman Chan

    (Department of Neurology,)

  • Noelia V. Weisstaub

    (Department of Psychiatry,
    Sackler Institute Laboratories and,)

  • Juan F. López-Giménez

    (Institute of Biomedical and Life Sciences, University of Glasgow)

  • Mingming Zhou

    (Department of Psychiatry,)

  • Yuuya Okawa

    (Department of Neurology,)

  • Luis F. Callado

    (CIBER of Mental Health, and,
    University of the Basque Country, E-48940 Leioa, Bizkaia, Spain)

  • Graeme Milligan

    (Institute of Biomedical and Life Sciences, University of Glasgow)

  • Jay A. Gingrich

    (Department of Psychiatry,
    Sackler Institute Laboratories and,
    Lieber Center for Schizophrenia Research, Columbia University, and the New York State Psychiatric Institute, New York, New York 10032, USA)

  • Marta Filizola

    (Department of Structural and Chemical Biology and,)

  • J. Javier Meana

    (CIBER of Mental Health, and,
    University of the Basque Country, E-48940 Leioa, Bizkaia, Spain)

  • Stuart C. Sealfon

    (Department of Neurology,
    Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York 10029, USA)

Abstract

Psychosis complex isolated New-generation antipsychotic drugs such as olanzapine and risperidone act by blocking neurotransmission by serotonin 2AR receptors; hallucinogens such as LSD also act via these receptors. And drugs that mimic the excitatory neurotransmitter glutamate at its mGluR2 receptor are also powerful antipsychotics. These and other lines of evidence suggest that the serotonin and glutamate neurotransmitter systems function abnormally in the brain in schizophrenia. This would seem to be confirmed with the surprising discovery of a functional complex containing the serotonin 2AR and mGluR2 receptors that is involved in the unique effects of chemical hallucinogens in cultured cells and mice. The balance of these two receptors is disrupted in the brains of schizophrenic subjects, further implicating this complex as a promising potential target for the treatment of psychosis.

Suggested Citation

  • Javier González-Maeso & Rosalind L. Ang & Tony Yuen & Pokman Chan & Noelia V. Weisstaub & Juan F. López-Giménez & Mingming Zhou & Yuuya Okawa & Luis F. Callado & Graeme Milligan & Jay A. Gingrich & Ma, 2008. "Identification of a serotonin/glutamate receptor complex implicated in psychosis," Nature, Nature, vol. 452(7183), pages 93-97, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06612
    DOI: 10.1038/nature06612
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