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Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

Author

Listed:
  • Jyh-Rong Chao

    (Department of Biochemistry,)

  • Evan Parganas

    (Department of Biochemistry,)

  • Kelli Boyd

    (Animal Resources Center, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA)

  • Cheol Yi Hong

    (Department of Biochemistry,)

  • Joseph T. Opferman

    (Department of Biochemistry,)

  • James N. Ihle

    (Department of Biochemistry,)

Abstract

Insights into the function of Hax1 are provided by a study showing that Hax1 facilitates the processing of the mitochondrial protease HtrA2 by the mitochondrial rhomboid protease Parl. It is the protease activity of HtrA2 that is essential to suppress apoptosis in both lymphocytes and striatal neurons.

Suggested Citation

  • Jyh-Rong Chao & Evan Parganas & Kelli Boyd & Cheol Yi Hong & Joseph T. Opferman & James N. Ihle, 2008. "Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons," Nature, Nature, vol. 452(7183), pages 98-102, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06604
    DOI: 10.1038/nature06604
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