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Stem-cell therapy for cardiac disease

Author

Listed:
  • Vincent F. M. Segers

    (Brigham and Women's Hospital, Harvard Medical School, Partners Research Facility)

  • Richard T. Lee

    (Brigham and Women's Hospital, Harvard Medical School, Partners Research Facility)

Abstract

Heart failure is the leading cause of death worldwide, and current therapies only delay progression of the disease. Laboratory experiments and recent clinical trials suggest that cell-based therapies can improve cardiac function, and the implications of this for cardiac regeneration are causing great excitement. Bone-marrow-derived progenitor cells and other progenitor cells can differentiate into vascular cell types, restoring blood flow. More recently, resident cardiac stem cells have been shown to differentiate into multiple cell types present in the heart, including cardiac muscle cells, indicating that the heart is not terminally differentiated. These new findings have stimulated optimism that the progression of heart failure can be prevented or even reversed with cell-based therapy.

Suggested Citation

  • Vincent F. M. Segers & Richard T. Lee, 2008. "Stem-cell therapy for cardiac disease," Nature, Nature, vol. 451(7181), pages 937-942, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06800
    DOI: 10.1038/nature06800
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    Cited by:

    1. Joshua Mayourian & Ruben M Savizky & Eric A Sobie & Kevin D Costa, 2016. "Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes," PLOS Computational Biology, Public Library of Science, vol. 12(7), pages 1-29, July.
    2. Miles Miller & Marc Hafner & Eduardo Sontag & Noah Davidsohn & Sairam Subramanian & Priscilla E M Purnick & Douglas Lauffenburger & Ron Weiss, 2012. "Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity," PLOS Computational Biology, Public Library of Science, vol. 8(7), pages 1-18, July.

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