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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

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  • Zoltan Arany

    (Harvard Medical School, Boston, Massachusetts 02115, USA
    Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA)

  • Shi-Yin Foo

    (Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA)

  • Yanhong Ma

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jorge L. Ruas

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Archana Bommi-Reddy

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Geoffrey Girnun

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Marcus Cooper

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Dina Laznik

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jessica Chinsomboon

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Shamina M. Rangwala

    (Novartis Institutes for Biomedical Research, Diabetes and Metabolism, Cambridge, Massachusetts 02139, USA)

  • Kwan Hyuck Baek

    (Vascular Biology Program, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Anthony Rosenzweig

    (Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA)

  • Bruce M. Spiegelman

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Countering ischaemia The transcriptional regulator PGC-1α mediates many of the effects of exercise on skeletal muscle, including mitochondrial biogenesis and fibre-type switching. Now this protein has been found to activate a natural defence pathway that protects ischaemic tissues. PGC-1α is produced in response to hypoxia and nutrient deprivation, and it in turn induces VEGF to promote blood vessel formation. This pathway is separate from the hypoxia response pathway involving hypoxia inducible factor and may provide a novel therapeutic target for treating ischaemic diseases of the heart, brain and limbs.

Suggested Citation

  • Zoltan Arany & Shi-Yin Foo & Yanhong Ma & Jorge L. Ruas & Archana Bommi-Reddy & Geoffrey Girnun & Marcus Cooper & Dina Laznik & Jessica Chinsomboon & Shamina M. Rangwala & Kwan Hyuck Baek & Anthony Ro, 2008. "HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α," Nature, Nature, vol. 451(7181), pages 1008-1012, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06613
    DOI: 10.1038/nature06613
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    Cited by:

    1. Ye Rim Cho & Ji Hee Lim & Min Young Kim & Tae Woo Kim & Bo Young Hong & Yong-Soo Kim & Yoon Sik Chang & Hye Won Kim & Cheol Whee Park, 2014. "Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-12, January.

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