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A role for adult TLX-positive neural stem cells in learning and behaviour

Author

Listed:
  • Chun-Li Zhang

    (Howard Hughes Medical Institute
    Gene Expression Laboratory)

  • Yuhua Zou

    (Gene Expression Laboratory)

  • Weimin He

    (Gene Expression Laboratory
    Present address: The Institute of Biosciences and Technology, 2121 W. Holcombe Boulevard, Houston, Texas 77030, USA.)

  • Fred H. Gage

    (Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA)

  • Ronald M. Evans

    (Howard Hughes Medical Institute
    Gene Expression Laboratory)

Abstract

Neural stem cells in learning The production of new neurons occurs in the adult brain, and appears to be influenced by external stimuli such as learning, exercise and stress. But it is not clear how the process is regulated or whether it is important for brain function. New work in knockout mice lacking the orphan nuclear receptor TLX, which is expressed in neural stem cells, suggests that adult neurogenesis plays a pivotal role in learning and memory. The mice had reduced stem-cell proliferation, and a marked decrease in spatial learning. But since other behaviours such as fear conditioning were unaffected, the new neurons appear to have a selective contribution to brain functions.

Suggested Citation

  • Chun-Li Zhang & Yuhua Zou & Weimin He & Fred H. Gage & Ronald M. Evans, 2008. "A role for adult TLX-positive neural stem cells in learning and behaviour," Nature, Nature, vol. 451(7181), pages 1004-1007, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06562
    DOI: 10.1038/nature06562
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