IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v451y2008i7178d10.1038_nature06504.html
   My bibliography  Save this article

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

Author

Listed:
  • Edward J. Miller

    (Cardiovascular Medicine Section of the Department of Internal Medicine,)

  • Ji Li

    (Cardiovascular Medicine Section of the Department of Internal Medicine,
    Present address: University of Wyoming School of Pharmacy, Laramie, Wyoming 82072, USA.)

  • Lin Leng

    (Rheumatology Section of the Department of Internal Medicine,)

  • Courtney McDonald

    (Rheumatology Section of the Department of Internal Medicine,)

  • Toshiya Atsumi

    (Hokkaido University, Sapporo, 060-8638, Japan)

  • Richard Bucala

    (Rheumatology Section of the Department of Internal Medicine,
    and)

  • Lawrence H. Young

    (Cardiovascular Medicine Section of the Department of Internal Medicine,
    Yale University School of Medicine, New Haven, Connecticut 06520, USA)

Abstract

The heart under stress AMPK (AMP-activated protein kinase) is a master regulator of many biological processes and is a potential drug target for diseases as diverse as diabetes, cancer, atherosclerosis and ischaemic heart disease. In the ischaemic heart, AMPK protects tissues from injury and apoptosis by promoting glucose uptake. A new study shows that AMPK is activated by the inflammatory cytokine MIF (macrophage migration inhibitory factor), which is released by the heart under ischaemic stress. This throws new light on the nature of the cellular stress response, and highlights low MIF levels as a potential risk marker for patients with coronary artery disease.

Suggested Citation

  • Edward J. Miller & Ji Li & Lin Leng & Courtney McDonald & Toshiya Atsumi & Richard Bucala & Lawrence H. Young, 2008. "Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart," Nature, Nature, vol. 451(7178), pages 578-582, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06504
    DOI: 10.1038/nature06504
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06504
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06504?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06504. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.